Cardioprotection by Volatile Anaesthetics: Anaesthetic-induced Preconditioning

REZUMAT Correspondence to: REVIEW ARTICLES CARDIOPROTECTION BY VOLATILE ANAESTHETICS: ANAESTHETIC-INDUCED PRECONDITIONING Octavian Toma, Wolfgang Schlack Precondi]ionarea anestezic\ a miocardului este un fenomen bine precizat prin care anestezicele volatile induc un efect cardioprotectiv care persist\ un anumit timp dup\ întreruperea anestezicului. Anestezicele volatile reduc necroza/apoptoza miocitelor cardiace prin activarea de multiple mecanisme moleculare care nu sunt înc\ pe deplin caracterizate. Materialul de fa]\ trece în revist\ dovezile experimentale [i clinice asupra posibilelor mecanisme ce mediaz\ efectele protective cardiace ale precondi]ion\rii prin anestezice volatile. Anaesthetic-induced preconditioning of the heart has now become a well accepted phenomenon, where the delivery of a volatile anaesthetic induces a longer lasting cardioprotective effect. Volatile anaesthetics can reduce necrotic/apoptotic myocardial cell death through activation of multiple molecular pathways. We are just at the beginning of understanding the precise mechanisms which mediate preconditioning by volatile anaesthetics. The present material provides an overview of our current knowledge of the mechanisms of cardioprotection by volatile anaesthetics.